Histological Alteration Induced by Manganese chloride in the Male Testes, Epididymis and Kidney of the Albino Rats

In Iraq. the municipalities are responsible for the production and delivery of drinking water (DW) .The quality of DW in Iraq is greatly deteriorated because of the war operation in this country Objective to study the effects of manganese chloride on histological testes, epididymis and kidney of rats and explore the dose –effects and time effects .The rats are randomly divided into six treatment groups with manganese chloride (60,80,100 ppm) and 2 control groups with N.S. After two different periods (3 and 6 mn.) oral administration Mncl2 by drinking water (60, 80,100 ppm) to investigate testicular and epididymis histological alterations of manganese chloride caused interstitial and tubular histological alterations that include atrophy of seminiferous tubules ,autolysis and granulolysis of epididymis. Histopathological, the most striking lesion were observed in the kidney .the high dose of Mn+2 (100 ppm) for two periods caused on opposite effect on nephrotoxicity. Causing exacerbation in the tubular necrosis. KeywordHistological alteration, Liver, Manganese chloride, Rat, Reproductive system